The 2000 United States Senate election in Michigan was held on November 7, 2000. Incumbent Republican U.S. Senator Spencer Abraham ran for re-election to a second term, but he was narrowly defeated by his Democratic opponent, congresswoman Debbie Stabenow. Stabenow subsequently made history as the first woman to represent Michigan in the United States Senate. By a margin of 1.6%, this election was the second-closest race of the 2000 Senate election cycle, behind only the election in Washington.

Edward Spencer Abraham is an American attorney, author, and politician who served as the 10th United States Secretary of Energy from 2001 to 2005, under President George W. Bush. A member of the Republican Party, he previously served as a United States Senator from Michigan from 1995 to 2001. Abraham is one of the founders of the Federalist Society, and a co-founder of the Harvard Journal of Law and Public Policy. As of 2023, he remains the last Republican to serve as a U.S. senator from Michigan.