The 2000 United States Senate election in Tennessee took place on November 7, 2000, as part of the general election including the 2000 U.S. presidential election, elections to the House of Representatives and various state and local elections. Incumbent Republican U.S. Senator Bill Frist won re-election to a second term, defeating Democratic candidate Jeff Clark.

The 2006 United States Senate election in Tennessee was held on November 7, 2006. Incumbent Republican Senator Bill Frist, the Majority Leader, retired after two terms in office. The open seat was won by Republican nominee Bob Corker, who defeated Democratic nominee Harold Ford Jr.