2001: A Space Odyssey is an oversized American comic book adaptation of the 1968 film of the same name as well as a ten-issue monthly series which expanded upon the concepts presented in the Stanley Kubrick film and the novel by Arthur C. Clarke. Jack Kirby wrote and pencilled both the adaptation and the series, which were published by Marvel Comics beginning in 1976. The adaptation was part of the agreement of Kirby's return to Marvel.

Marvel Comics is an American comic book publisher and the property of The Walt Disney Company since December 31, 2009, and a subsidiary of Disney Publishing Worldwide since March 2023. Marvel was founded in 1939 by Martin Goodman as Timely Comics, and by 1951 had generally become known as Atlas Comics. The Marvel era began in August 1961 with the launch of The Fantastic Four and other superhero titles created by Stan Lee, Jack Kirby, Steve Ditko, and many others. The Marvel brand, which had been used over the years and decades, was solidified as the company's primary brand.