The 2001 American League Championship Series (ALCS) was a rematch of the 2000 ALCS between the New York Yankees, who had come off a dramatic comeback against the Oakland Athletics in the Division Series after being down two games to zero, and the Seattle Mariners, who also rallied to win their Division Series in five games over the Cleveland Indians. The series had additional poignancy, coming immediately after New York City was devastated by the September 11 attacks.

The 2000 American League Championship Series (ALCS) was a matchup between the East Division champion New York Yankees and the Wild Card Seattle Mariners. The Yankees had advanced to the Series after beating the West Division champion Oakland Athletics in the ALDS three games to two and the Mariners advanced by beating the Central Division champion Chicago White Sox three games to none. The Yankees won the Series four games to two and went on to defeat the New York Mets in the World Series to win their third consecutive World Series championship, 26th overall.