The 2001 Cincinnati Reds season was the 132nd season for the franchise in Major League Baseball. It consisted of the Cincinnati Reds attempting to win the National League Central. The Reds were managed by Bob Boone.

The 2001 Major League Baseball season finished with the Arizona Diamondbacks defeating the New York Yankees in seven games for the World Series championship. The September 11 terrorist attacks on New York and Washington, D.C. pushed the end of the regular season from September 30 to October 7. Because of the attacks, the World Series was not completed until November 4. The 2001 World Series was the first World Series to end in November.