The 2001 Protection One 400 was a NASCAR Winston Cup Series stock car race held on September 30, 2001, at Kansas Speedway in Kansas City, Kansas. The race was the 28th of the 2001 NASCAR Winston Cup Series season. The race was the inaugural Cup race held at the 1.5-mile (2.4 km) track. Jason Leffler from Chip Ganassi Racing won his first career pole position with a qualifying speed of 176.499 miles per hour (284.048 km/h). Penske Racing's Rusty Wallace led the most laps with 117, while Jeff Gordon of Hendrick Motorsports won the race.

Jason Charles Leffler was an American professional open-wheel and stock car racing driver. Leffler began racing in the open-wheel ranks, competing in the 2000 Indianapolis 500 before moving to primarily NASCAR competition. He died from injuries sustained in a 410 sprint car race at Bridgeport Speedway in Bridgeport, New Jersey.