The 2004 United States Senate election in Alaska took place on November 2, 2004, alongside other elections to the United States Senate in other states as well as elections to the United States House of Representatives, various state and local elections, and the presidential election of that year. Incumbent Republican U.S. Senator Lisa Murkowski of Anchorage, sought election to her first full term after being appointed by her father Frank Murkowski to serve out the rest of the latter's unexpired term when he resigned in December 2002 to become Governor of Alaska. Her main challenger was Democratic former governor Tony Knowles, her father's predecessor as governor. Murkowski won by a slight margin. As of 2022, Senator Murkowski’s vote total of 149,773 votes remains the most raw votes she has ever received during any of her runs for the US Senate.

Lisa Ann Murkowski is an American attorney and politician serving as the senior United States senator representing Alaska, having held that seat since 2002. She is the first woman to represent Alaska in the Senate and the Senate's second-most senior Republican woman, after Susan Collins of Maine. She became dean of Alaska's congressional delegation upon Representative Don Young's death.