The 2004 United States Senate election in North Carolina was held on November 2, 2004. Incumbent Democratic U.S. Senator John Edwards decided to retire from the Senate after one term in order to run unsuccessfully for the 2004 Democratic Party presidential nomination, and become his party's vice presidential nominee. Republican Richard Burr won the open seat, making it the fifth consecutive election in which partisan control of the seat changed.

Johnny Reid Edwards is an American lawyer and former politician who served as a U.S. senator from North Carolina. He was the Democratic nominee for vice president in 2004 alongside John Kerry, losing to incumbents George W. Bush and Dick Cheney. He also was a candidate for the Democratic presidential nomination in 2004 and 2008.