The 2005 Giro d'Italia was the 88th edition of the Giro d'Italia, one of cycling's Grand Tours. It began in Reggio Calabria with a 1.15 km (0.7 mi) prologue. The race came to a close with a 119 km (73.9 mi) mass-start road stage that stretched from Albese con Cassano to Milan. Twenty two teams entered the race that was won by the Italian Paolo Savoldelli of the Discovery Channel team. Second and third were the Italian Gilberto Simoni and Venezuelan José Rujano.

The Giro d'Italia is an annual multiple-stage bicycle race primarily held in Italy, while also starting in, or passing through, other countries. The first race was organized in 1909 to increase sales of the newspaper La Gazzetta dello Sport, and the race is still run by a subsidiary of that paper's owner. The race has been held annually since its first edition in 1909, except during the two world wars. As the Giro gained prominence and popularity, the race was lengthened, and the peloton expanded from primarily Italian participation to riders from all over the world. The Giro is a UCI World Tour event, which means that the teams that compete in the race are mostly UCI WorldTeams, with some additional teams invited as 'wild cards'.