The 2005 Major League Baseball All-Star Game was the 76th playing of the midseason exhibition baseball game between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 12, 2005 at Comerica Park in Detroit, Michigan, the home of the Detroit Tigers of the American League. The game resulted in the American League defeating the National League 7–5, thus awarding an AL team home-field advantage in the 2005 World Series. In this game Rawlings first previewed the Coolflo batting helmets, which became standard the followig season.

Comerica Park is a baseball stadium located in Downtown Detroit. It has been the ballpark of Major League Baseball's Detroit Tigers since 2000, when the team left Tiger Stadium.