2005 saw the release of many sequels and prequels in video games, such as Grand Theft Auto: Liberty City Stories, Tony Hawk's American Wasteland, Resident Evil 4, Black & White 2, Brothers in Arms: Road to Hill 30, Devil May Cry 3: Dante's Awakening, Mario Kart DS, Mario & Luigi: Partners in Time, Myst V: End of Ages, Need for Speed: Most Wanted, and Prince of Persia: The Two Thrones, alongside prominent new releases including Brain Age, F.E.A.R., Forza Motorsport, Dinosaur King, God of War, Guild Wars, Guitar Hero, Nintendogs, Onechanbara, Shadow of the Colossus, Madden NFL 06, NBA Live 06, NBA 2K6, WWE Smackdown! vs. Raw 2006, and Sniper Elite. The seventh generation of video game consoles also began with the launch of the Xbox 360, while the Nintendo DS launched in PAL regions.

Resident Evil 4 is a survival horror game by Capcom, originally released for the GameCube in 2005. Players control the special agent Leon S. Kennedy on a mission to rescue the US president's daughter, Ashley Graham, who has been kidnapped by a religious cult in rural Spain. Leon fights hordes of enemies infected by a mind-controlling parasite and reunites with the spy Ada Wong. In a departure from the fixed camera angles and slower gameplay of previous Resident Evil games, Resident Evil 4 features a dynamic camera system and action-oriented gameplay.