ANAPROF 2006 is the 2006 season of the Panamanian football (soccer) league, ANAPROF. The season started on February 3, 2006 with the "Torneo Apertura 2006" and finalized on November 25, 2006 with the Torneo Clausura 2006. The Apertura champion was San Francisco F.C. and the Clausura champion was Tauro F.C., on December 3, 2006 the ANAPROF 2006 final was played and San Francisco was crowned champion over Tauro.

The Liga Panameña de Fútbol is the top division football league in Panama. Until 2009, the league was named Asociación Nacional Pro Fútbol (ANAPROF).