The 2006 Brazilian Grand Prix was a Formula One motor race held on 22 October 2006 at the Autódromo José Carlos Pace, São Paulo. It was the eighteenth and final race of the 2006 FIA Formula One World Championship. The race determined the Drivers' and Constructors' Championships for the season, with Fernando Alonso and Renault winning their respective championships. The race itself attracted 154 million viewers.

The Autódromo José Carlos Pace, better known as Autódromo de Interlagos or simply Interlagos, is a 4.309 km (2.677 mi) motorsport circuit located in the city of São Paulo, Brazil. It was inaugurated on 12 May 1940, by the federal intervener of the São Paulo province, Adhemar de Barros. The traditional name of the circuit and of the neighborhood itself comes from the fact that it is located in a region between two large artificial lakes, Guarapiranga and Billings, which were built in the beginning of the 20th century to supply the city with water and electricity. In 1985, the circuit was renamed to honor the Formula 1 driver José Carlos Pace, who died in a plane crash in 1977. Attached to its facilities there is a kart circuit named after Ayrton Senna. The circuit runs counterclockwise.