The 2006 Democrats 66 leadership election was called to elect the new leader of the Democrats 66 after incumbent Boris Dittrich announced his retirement from national politics. Dittrich, who had been the leader of the party since the resignation of Thom de Graaf on 22 January 2003, did not stand for the leadership election. Alexander Pechtold won the election, beating Lousewies van der Laan and six others.

The Leader of the Democrats 66 is the most senior politician within the Democrats 66 party in the Netherlands. The post is currently held by Rob Jetten who was elected on 12 August 2023 and will lead the party into the 2023 Dutch general election. Jetten previously served as parliamentary leader of D66 in the House of Representatives from 2018 to 2021 and as Minister for Climate and Energy in the fourth Rutte government.