The 2006 Giro d'Italia was the 89th edition of the Giro d'Italia, one of cycling's Grand Tours. It began in the Belgian city of Seraing with a 6.2 km (3.9 mi) individual time trial. The race came to a close with a 140 km (87.0 mi) mass-start road stage that stretched from Museo del Ghisallo to Milan. Twenty two teams entered the race that was won by the Italian Ivan Basso of the Team CSC team. Second and third were the Spain José Enrique Gutiérrez and Italian Gilberto Simoni.

The Giro d'Italia is an annual multiple-stage bicycle race primarily held in Italy, while also starting in, or passing through, other countries. The first race was organized in 1909 to increase sales of the newspaper La Gazzetta dello Sport, and the race is still run by a subsidiary of that paper's owner. The race has been held annually since its first edition in 1909, except during the two world wars. As the Giro gained prominence and popularity, the race was lengthened, and the peloton expanded from primarily Italian participation to riders from all over the world. The Giro is a UCI World Tour event, which means that the teams that compete in the race are mostly UCI WorldTeams, with some additional teams invited as 'wild cards'.