The 2006 Major League Baseball season ended with the National League's St. Louis Cardinals winning the World Series with the lowest regular-season victory total (83) in a fully-played season in major league history. The Atlanta Braves failed to qualify for the postseason for the first time since 1990. Individual achievements included Barry Bonds who, despite questions surrounding his alleged steroid use and involvement in the BALCO scandal, surpassed Babe Ruth for second place on the career home runs list. The American League continued its domination at the All-Star Game by winning its fourth straight game, and ninth of the prior 10 contests.

The 2006 World Series was the championship series of Major League Baseball's (MLB) 2006 season. The 102nd edition of the World Series, it was a best-of-seven playoff between the American League (AL) champion Detroit Tigers and the National League (NL) champion St. Louis Cardinals; the Cardinals won the series in five games to win their tenth World Series championship. This was the third World Series meeting between the Tigers and the Cardinals, the first in 38 years. The Cardinals won the first in 1934, and the Tigers won the second in 1968; each went the full seven games.