The 2006 South Carolina gubernatorial election took place on November 7, 2006. Incumbent Republican Governor Mark Sanford won re-election against Democratic State Senator Tommy Moore, becoming only the third Republican governor in South Carolina to win a second term. Sanford started the campaign with a double-digit edge over Moore and he maintained that lead to election day. During the campaign, Sanford's approval rating averaged in the mid-fifties. In Sanford's re-election victory, he also garnered 22% of the African American vote.

Marshall Clement "Mark" Sanford Jr. is an American politician and author who served as the U.S. representative for South Carolina's 1st congressional district from 1995 to 2001 and from 2013 to 2019, and as the 115th governor of South Carolina from 2003 to 2011. He is a member of the Republican Party.