The 2006 UCI Cyclo-cross World Championships were held in Zeddam, the Netherlands from Saturday January 28 to Sunday January 29, 2006.

The UCI Cyclo-cross World Championships are the world championships for cyclo-cross organised by the Union Cycliste Internationale (UCI). Starting in 2020, six events are organized each year – men's elite, women's elite, men's under 23, women's under 23, men's under 18, and women's under 18. Traditionally, the elite events are held on a Sunday with the other events held on the Saturday the day before.