Two-time defending champion Roger Federer defeated Andy Roddick in the final, 6–2, 4–6, 7–5, 6–1 to win the men's singles tennis title at the 2006 US Open. It was his third US Open title and ninth major title overall. Federer became the sixth man to reach all four major finals in one calendar year, the second to do so in the Open Era, and the first to do so since Laver in 1969. Also, he reached a record-equaling 10th consecutive major semifinal, matching Laver and Ivan Lendl.

Andre Kirk Agassi is an American former world No. 1 tennis player. He is an eight-time major champion, an Olympic gold medalist, and a runner-up in seven other majors. Widely considered one of the greatest tennis players of all time, Agassi is the second of five men to achieve the career Grand Slam in the Open Era and the fifth of eight overall to make the achievement. He is also the first of two men to achieve the career Golden Slam, as well as the only man to win a career Super Slam.