The 2006 United States Senate election in Indiana was held November 7, 2006. Incumbent Republican United States Senator Richard Lugar was re-elected to his sixth six-year term with 87.3% of the vote. He did not have a Democratic opponent and only faced opposition from a Libertarian candidate; this was the only U.S. Senate race in 2006 in which Democrats did not field a candidate. This would be the last successful race of Lugar's decades long political career. This is also the last time that Lake, Marion, and Monroe counties have voted for a Republican candidate for Senate.

The 2012 United States Senate election in Indiana took place on November 6, 2012, concurrently with the U.S. presidential election as well as other elections to the United States Senate and House of Representatives and various state and local elections.