The 2006 Wake Forest Demon Deacons football team represented Wake Forest University during the 2006 NCAA Division I FBS football season. The team was coached by Jim Grobe, in his fifth season at the school, and played its home games at Groves Stadium. The Deacons finished the regular season with a 10–2 record, giving them the first 10-win season in their history, and won the Atlantic Division of the Atlantic Coast Conference. The subsequent victory in the conference championship game gave Wake Forest their first conference championship in 36 years. As such, they represented the ACC in the Orange Bowl. The team ended the season with an 11–3 record and a number 17 ranking in the nation. The team and its star linebacker Jon Abbate would become the subject of a 2011 feature film, The 5th Quarter. They did not win the Atlantic Division again until 2021.

The 2006 Georgia Tech Yellow Jackets football team represented the Georgia Institute of Technology in the 2006 NCAA Division I FBS football season. The team's coach was former Dallas Cowboys, Samford Bulldogs, and Troy Trojans coach Chan Gailey. The Yellow Jackets played their home games at Bobby Dodd Stadium in Atlanta.