The 2006 West Virginia Senate election took place on Tuesday, November 7, 2006, to elect members to the 78th and 79th Legislature. 17 of the 34 state senate seats were up for election. State senate seats in West Virginia are staggered, with senators serving 4-year terms. The election took place concurrently with the U.S. House and U.S. Senate elections. The Democratic Party won over 60% of the vote for state senate candidates and picked up 2 seats held by Republicans, retaining their supermajority. While President George W. Bush won the state in the previous presidential election, Democrats did well across the country and the state in a year described as a blue wave.

The 2004 West Virginia Senate election took place on Tuesday, November 2, 2004, to elect members to the 77th and 78th Legislatures; held concurrently with the presidential, U.S. House, and gubernatorial elections. State senate seats in West Virginia are staggered, with senators serving 4-year terms. 17 of the 34 state senate seats were up for election. While Republican candidate for George W. Bush won the state in the presidential election by 13 points, the Democratic Party won a majority of the vote for state senate candidates. Republicans managed to flip 3 seats, chipping away at the Democrats' supermajority.