General elections were held in Zambia on 28 September 2006 to elect a President, members of the National Assembly and local government councillors. The result was a victory for the ruling Movement for Multi-Party Democracy, which won 75 of the 150 National Assembly seats and whose candidate, Levy Mwanawasa, won the presidential vote. Voter turnout was just over 70%.

The president of Zambia is the head of state and the head of government of Zambia. The office was first held by Kenneth Kaunda following independence in 1964. Since 1991, when Kaunda left the presidency, the office has been held by seven others: Frederick Chiluba, Levy Mwanawasa, Rupiah Banda, Michael Sata, Edgar Lungu and the current president Hakainde Hichilema, who won the 2021 presidential election. In addition, acting president Guy Scott served in an interim capacity after the death of President Michael Sata.