The 2007 Major League Baseball season began on April 1 with a rematch of the 2006 National League Championship Series; the St. Louis Cardinals and New York Mets played the first game of the season at Busch Stadium in St. Louis, Missouri, which was won by the Mets, 6–1. The regular season concluded with seven teams entering the postseason who had failed to reach the 2006 playoffs including all National League teams, with only the New York Yankees returning; a dramatic one-game playoff between the Colorado Rockies and San Diego Padres; and the largest September collapse for a leading team in baseball history, with the Mets squandering a 7-game lead with 17 to play, losing on the final day of the regular season, and the Philadelphia Phillies capturing the National League East for the first time since 1993. The season ended on October 28, with the Boston Red Sox sweeping the World Series over the Rockies, four games to zero.

The 2007 National League Wild Card tie-breaker game was a one-game extension to Major League Baseball's (MLB) 2007 regular season, played between the San Diego Padres and Colorado Rockies of the National League's (NL) West Division to determine the NL wild card. It was played at Coors Field in Denver, Colorado, on October 1, 2007. The Rockies won the game 9–8 in thirteen innings on a controversial play at home plate.