The 2008 Clemson Tigers football team represented Clemson University in the 2008 NCAA Division I FBS football season. The Tigers were led by head coach Tommy Bowden, who resigned six games into his tenth season. The interim head coach was assistant coach Dabo Swinney. The Tigers play their home games in Memorial Stadium.

The 2008 NCAA Division I FBS football season was the highest level of college football competition in the United States organized by the National Collegiate Athletic Association (NCAA).