The 2008 Daytona 500, the 50th annual running of the event, was held on February 17, 2008 at Daytona International Speedway in Daytona Beach, Florida. The race was the 50th to be run since the first in 1959, won by Lee Petty. To commemorate the event, the Harley J. Earl Trophy, which goes to the winner of the race, was plated in gold instead of silver. In addition, the winning car was placed on display for one year at the Daytona 500 Experience attraction just outside Turn Four. Ryan Newman won the race, his only win in the 2008 season and his final win for team owner Roger Penske.

The Daytona 500 is a 500-mile-long (805 km) NASCAR Cup Series motor race held annually at Daytona International Speedway in Daytona Beach, Florida. It is the first of two Cup races held every year at Daytona, the second being the Coke Zero Sugar 400, and one of three held in Florida, with the annual fall showdown Dixie Vodka 400 being held at Homestead south of Miami. From 1988 to 2019, it was one of the four restrictor plate races on the Cup schedule. The inaugural Daytona 500 was held in 1959 coinciding with the opening of the speedway and since 1982, it has been the season-opening race of the Cup series.