The 2008 NBA All-Star Game was an exhibition basketball game that was played on February 17, 2008, during the National Basketball Association's (NBA) 2007–08 season. It was the 57th edition of the NBA All-Star Game, and was played at New Orleans Arena in New Orleans, home of the New Orleans Hornets. The Eastern Conference defeated the Western Conference, 134–128. LeBron James was named the All-Star Game Most Valuable Player, his second time winning the award. This was the first NBA All-Star Game that was hosted by New Orleans, and was the city's first major professional sporting event since the area was devastated by Hurricane Katrina in 2005. The city was awarded in an announcement by commissioner David Stern on May 22, 2006. The other reported contenders for the 2008 contest was Air Canada Centre at Toronto, who withdrew the bid early in 2005.

Smoothie King Center is a multi-purpose indoor arena in New Orleans, Louisiana. It is located in the city's Central Business District, adjacent to Caesars Superdome. The arena opened in 1999 as New Orleans Arena and has been home to the New Orleans Pelicans of the National Basketball Association (NBA) since 2002. The New Orleans VooDoo of the Arena Football League played their home games in the arena from 2004 until the team disbanded in 2008. The VooDoo resumed play at the arena in March 2011, until after the 2015 AFL season when the franchise folded.