The 2008 Preakness Stakes was the 133rd running of the Preakness Stakes thoroughbred horse race. The race time was at 6:15 pm EDT and was televised in the United States on the NBC television network. Big Brown, the 1-5 favorite, was the winner by 51⁄4 lengths over Macho Again. Approximate post time was 6:17 p.m. Eastern Time. The race was run over a fast track in a final time of 1:54.80. The Maryland Jockey Club reported total attendance of 121,876, the second highest attended American thoroughbred racing event in 2008.

The Preakness Stakes is an American thoroughbred horse race held annually on Armed Forces Day, the third Saturday in May at Pimlico Race Course in Baltimore, Maryland. The Preakness Stakes is a Grade I race run over a distance of 1+3⁄16 miles on dirt. Colts and geldings carry 126 pounds (57 kg); fillies 121 pounds (55 kg). It is the second jewel of the Triple Crown, held two weeks after the Kentucky Derby and three weeks before the Belmont Stakes.