The 2008 United States Senate election in Wyoming took place on November 4, 2008. Incumbent Republican U.S. Senator Mike Enzi won re-election to a third term.

Michael Bradley Enzi was an American politician who served in the United States Senate from Wyoming as a member of the Republican Party from 1997 to 2021. Prior to his tenure in the United States Senate he served as mayor of Gillette, Wyoming, in the Wyoming House of Representatives from Campbell County, and the Wyoming Senate from the 24th district. He was the longest-serving senator from Wyoming since Francis E. Warren.