The 2008 United States presidential election in Missouri was held on November 4, 2008, and was part of the 2008 United States presidential election, which took place throughout all 50 states and D.C. Voters chose 11 representatives, or electors to the Electoral College, who voted for president and vice president.

Greene County is located in the southwest part of the U.S. state of Missouri. As of the 2020 census, its population was 298,915. making it the fourth most-populous county in Missouri.