The 2010 Valero Alamo Bowl game was the 18th edition of the annual college football bowl game known previously as the Alamo Bowl. It was played on December 29, 2010 between the Oklahoma State Cowboys and the Arizona Wildcats. ESPN television broadcast the game.

The Alamo Bowl is an NCAA Division I Football Bowl Subdivision college football bowl game played annually since 1993 in the Alamodome in San Antonio, Texas. Since 2010 it matches the second choice team from the Pac-12 Conference and the second choice team from the Big 12 Conference. Traditionally, the Alamo Bowl has been played in December, although it was played in January following the 2009, 2014, and 2015 seasons.