The 2010 Armenian Premier League season was the nineteenth since its establishment. The season began in March 2010 and ended in November 2010. FC Pyunik were the defending champions, having won their twelfth championship last season.

Ulisses Football Club, commonly known as Ulisses, is a defunct Armenian football club from Yerevan. The club played at the Armenian Premier League, the top division in Armenian football. They regularly used the Vazgen Sargsyan Republican Stadium in Yerevan and occasionally the City Stadium in Abovyan as their home ground.