The 21st Central American and Caribbean Games took place in Mayagüez, Puerto Rico, from 18 July 2010 to 1 August 2010.

The Central American and Caribbean Games are a multi-sport regional championship event, held quadrennial, typically in the middle (even) year between Summer Olympics. The games are for 32 countries and 5 territories in Central America, the Caribbean, Mexico, and the South American Caribbean countries of Colombia, Guyana, Suriname, and Venezuela.