The men's 100 metres at the 2010 European Athletics Championships was held at the Estadi Olímpic Lluís Companys on 27 and 28 July.

The 2010 European Athletics Championships were the 20th edition of the European Athletics Championships, organised under the supervision of the European Athletic Association. They were held at the Estadi Olímpic Lluís Companys in Barcelona, Catalonia, Spain from 27 July to 1 August 2010. Barcelona was the first Spanish city to host the European Championships.