Group F of the 2010 FIFA World Cup began on 14 June 2010 and ended on 24 June 2010. The group consisted of 2006 winner Italy, Paraguay, New Zealand and Slovakia. Italy and Paraguay previously met in the first round of the 1950 tournament, with Italy winning 2–0; neither qualified for the next round.

The Paraguay national football team represents Paraguay in men's international football competitions, and are controlled by the Paraguayan Football Association. Paraguay is a member of CONMEBOL. Their nickname is the Albirroja, or red and white. The Albirroja has qualified for eight FIFA World Cup competitions, with their best performance coming in 2010 when they reached the quarter-finals. A regular participant at the Copa América, Paraguay have been crowned champions of the competition on two occasions. Paraguay's highest FIFA World Rankings was 8th and their lowest was 103. Paraguay was awarded second place with Best Move of the Year in 1996 for their rise in the FIFA Rankings.