The 2010 Major League Baseball All-Star Game was the 81st midseason exhibition between the All-Stars of the American League (AL) and the National League (NL), the two leagues comprising Major League Baseball. The game was held on July 13, 2010, at Angel Stadium of Anaheim, the home of the American League Los Angeles Angels of Anaheim, and was telecast by Fox Sports in the US, with Joe Buck and Tim McCarver in the broadcast booth. Fox also teamed with DirecTV to produce a separate 3D broadcast, the first ever for a network Major League Baseball game. Kenny Albert and Mark Grace called the 3D telecast. ESPN Radio also broadcast the game, with Jon Sciambi and Dave Campbell announcing. The National League won the game 3–1, ending a 13-game winless streak.

The Major League Baseball All-Star Game, also known as the "Midsummer Classic", is an annual professional baseball game sanctioned by Major League Baseball (MLB) and contested between the all-stars from the American League (AL) and National League (NL). Starting fielders are selected by fans, pitchers are selected by managers, and reserves are selected by players and managers.