The 2010 Major League Baseball season began April 4, with the regular season ending on October 3. The 2010 All-Star Game was played on July 13 at Angel Stadium of Anaheim in Anaheim, California. The National League ended a 13-game winless streak with a 3–1 victory. Due to this result, the World Series began October 27 in the city of the National League Champion, the San Francisco Giants, and ended November 1 when the Giants defeated the American League Champion Texas Rangers, four games to one.

The Tampa Bay Rays' 2010 season was their 13th season in Major League Baseball. They improved on their 84–78 record from 2009 by finishing the regular season 96–66, and qualifying for the postseason for the second time in history by winning their second American League East championship in three years.