The 2010 Melon Music Awards were held on Wednesday, December 15, 2010, at the Hall of Peace of Kyung Hee University in Seoul, South Korea. Organized by Kakao M through its online music store Melon, the 2010 ceremony was the second installment of the event. The winners for the Top 10 Bonsang Award were announced prior to the ceremony.

The Melon Music Award for Artist of the Year is an accolade presented by Kakao M at the annual Melon Music Awards. The Artist of the Year award was first given at its inaugural online ceremony in 2005; since 2009, it consists of the most prestigious awards given at the event, alongside Album of the Year and Song of the Year.