The 2010 season was the Minnesota Vikings' 50th in the National Football League (NFL), and the fifth and final under head coach Brad Childress. After a loss to the New Orleans Saints in the NFC Championship ended their 2009 season, the Vikings had hoped to defend their NFC North division title for the third year in a row and contend again for a Super Bowl championship. However, Brett Favre was unable to recover from the injuries he had sustained in the NFC Championship and turned in abysmal performances for most of the season, being forced to sit out three games due to injuries and breaking his consecutive start record at 297 games since September 1992. After the Vikings fell to a 3–7 record with a 31–3 division loss to the Green Bay Packers in week 11, Childress was fired and defensive coordinator Leslie Frazier was named as his interim replacement, going 3–3 in his six games in charge before taking over the job permanently at the end of the season. The team finished 6–10 and ended up in last place in the division for the first time since 1990.

The 2010 NFL season was the 91st regular season of the National Football League (NFL) and the 45th of the Super Bowl era.