The 2010 Missouri State Auditor election took place on November 2, 2010. Republican Ambassador Tom Schweich defeated incumbent Democratic State Auditor Susan Montee. It was only the third time in the last four decades that a sitting auditor in Missouri was unseated. Schweich's victory made him one of only two Republicans elected to Missouri's executive branch.

Thomas A. Schweich was an American politician, diplomat, attorney, and author. A member of the Republican Party, Schweich served as State Auditor of Missouri from 2011 until his death in 2015.