The 2010 Mnet Asian Music Awards was the twelfth of the annual music awards in Seoul, South Korea that took place on November 28, 2010, at The Venetian Macao in Macau, China. About 10,000 people attended the awards ceremony.

2NE1 was a South Korean girl group formed by YG Entertainment, which was active between 2009 and 2016. The group was composed of four members: Bom, CL, Dara, and Minzy. Known for breaking typical stereotypes of K-pop, musical experimentation, fashion, and stage presence, they are recognized for expanding girl group styles in the Korean music industry and have become one of the leading figures of the Korean wave.