The 2010 NFL draft was the 75th annual meeting of National Football League (NFL) franchises to select newly eligible football players. The 2010 draft took place over three days, at Radio City Music Hall in New York City, with the first round on April 22, 2010. The second and third rounds took place on April 23, while the final four rounds were held on April 24. Television coverage was provided by both NFL Network and ESPN.

The National Football League draft, also called the NFL draft or (officially) the Annual Player Selection Meeting, is an annual event which serves as the most common source of player recruitment in the National Football League. Each team is given a position in the drafting order in reverse order relative to its record in the previous year, which means that the last place team is positioned first and the Super Bowl champion is last. From this position, the team can either select a player or trade its position to another team for other draft positions, a player or players, or any combination thereof. The round is complete when each team has either selected a player or traded its position in the draft. The first draft was held in 1936, and has been held every year since.