The 2010 NRL Grand Final was the conclusive and premiership-deciding game of the 2010 NRL season. Played on Sunday, 3 October at Sydney's ANZ Stadium, the match was contested by the St. George Illawarra Dragons and the Sydney Roosters. It was the first time the two sides met in a grand final. They had played each other twice before during the season, with St. George Illawarra winning on both occasions. St. George Illawarra finished the season as minor premiers as they had the previous season. The Roosters were the previous year's wooden-spooners and only after playing and winning for five consecutive weeks were able to reach the 2010 decider.

The St. George Illawarra Dragons are an Australian professional rugby league football club, representing both the Illawarra and St George regions of New South Wales. The club has competed in the National Rugby League (NRL) since 1999 after a joint-venture was formed between the St. George Dragons and the Illawarra Steelers. The club officially formed as the game's first joint-venture club on 23 September 1998 and remains the only inter-city team in the NRL. The team has its headquarters and leagues clubs in both Wollongong and the Sydney suburb of Kogarah, and trains and plays games regularly at WIN Stadium in Wollongong, as well as at Jubilee Oval in Kogarah. From 1999 to 2006 the club was jointly owned by the St. George Dragons 50% and Illawarra Steelers 50%. In 2006 WIN Corporation purchased 50% of the Illawarra Steelers stake in the club before purchasing the rest of the Illawarra Steelers' share in August 2018.