The 2010 Notre Dame Fighting Irish football team represented the University of Notre Dame in the 2010 NCAA Division I FBS football season. The team was coached by Brian Kelly and played its home games at Notre Dame Stadium in South Bend, Indiana. This was Kelly's first season as Notre Dame's head coach, after leading the Cincinnati Bearcats to a 12–0 regular season and BCS bowl berth. In 2010, Notre Dame's regular season schedule was ranked the most difficult schedule in the nation with a Team Opposition Record Percentage of .6529. They finished the season 8–5 and were invited to the Sun Bowl where they defeated the Miami Hurricanes, 33–17.

The 2010 NCAA Division I FBS football season was the highest level of college football competition in the United States organized by the National Collegiate Athletic Association (NCAA).