The 2010 Ole Miss Rebels football team represented the University of Mississippi during the 2010 NCAA Division I FBS football season. The team was coached by Houston Nutt, who was in his third season as the Rebels' head coach. Ole Miss has been a member of the Southeastern Conference (SEC) since the league's inception in 1932, and has participated in that conference's Western Division since its formation in 1992. The Rebels played seven home games in 2010 at Vaught–Hemingway Stadium in Oxford, Mississippi, which has been Ole Miss football's home since 1915. They finished the season 4–8, 1–7 in SEC play.

The 2010 NCAA Division I FBS football season was the highest level of college football competition in the United States organized by the National Collegiate Athletic Association (NCAA).