The 2010 San Diego Padres season was the 42nd season in franchise history. On August 25, the Padres had a 6+1⁄2-game lead over the second-place San Francisco Giants, but ended up missing the playoffs as the Giants passed them in September. This was the last winning season the Padres would have until 2020.

The 2010 Major League Baseball season began April 4, with the regular season ending on October 3. The 2010 All-Star Game was played on July 13 at Angel Stadium of Anaheim in Anaheim, California. The National League ended a 13-game winless streak with a 3–1 victory. Due to this result, the World Series began October 27 in the city of the National League Champion, the San Francisco Giants, and ended November 1 when the Giants defeated the American League Champion Texas Rangers, four games to one.