The 2010 San Francisco Giants season marked their 128th year in Major League Baseball, their 53rd year in San Francisco since their move from New York following the 1957 season, and their 11th in AT&T Park. The Giants won the National League West for the first time since the 2003 season and both the NLDS and NLCS for the first time since the 2002 season. They would go on to win the World Series, their first championship since moving to San Francisco in 1958. Giants catcher Buster Posey was awarded the National League Rookie of the Year Award.

The 2010 National League Division Series (NLDS) were two best-of-five-game series to determine the participating teams in the 2010 National League Championship Series. The three divisional winners and a fourth team—a "Wild Card"—played in two series from October 6 to 11. TBS televised all games in the United States.