The 2010 TUMS Fast Relief 500 was a NASCAR Sprint Cup Series stock car race that was held on October 24, 2010, at Martinsville Speedway in Martinsville, Virginia. It was contested over 500 laps, and was the thirty-second race of the season and the sixth race in the season-ending Chase for the Sprint Cup for the 2010 NASCAR Sprint Cup Series. The race was won by Denny Hamlin for the Joe Gibbs Racing team. Mark Martin driving for Hendrick Motorsports finished second and Richard Childress Racing's Kevin Harvick, who started thirty-sixth, came third.

Mark Anthony Martin is an American retired stock car racing driver. He has the second most wins all time in what is now the Xfinity Series with 49. He scored 40 Cup Series wins. He finished second in the NASCAR Cup Series standings five times, third in the NASCAR Cup Series standings four times, and has been described by ESPN as "The best driver to never win a championship." Martin also failed to win the Daytona 500 during his career. Martin has five IROC Championships, more than any other driver. Also, during the 2005 season, he took over the all-time record for IROC wins, with 13. Martin is the final driver born in the 1950s to win a NASCAR Cup Series race.