The 2010 United States House of Representatives elections were held on November 2, 2010, as part of the 2010 midterm elections during President Barack Obama's first term in office. Voters of the 50 U.S. states chose 435 U.S. Representatives to serve in the 112th United States Congress. Also, voters of the U.S. territories, commonwealths and District of Columbia chose their non-voting delegates. U.S. Senate elections and various state and local elections were held on the same date.

The United States House of Representatives is the lower chamber of the United States Congress, with the Senate being the upper chamber. Together, they comprise the national bicameral legislature of the United States. The House is charged with the passage of federal legislation, known as bills; those that are also passed by the Senate are sent to the president for signature or veto. The House's exclusive powers include initiating all revenue bills, impeaching federal officers, and electing the president if no candidate receives a majority of votes in the Electoral College.