The 2010 United States Senate election in Indiana took place on November 2, 2010, alongside 33 other elections to the United States Senate in other states and elections to the United States House of Representatives and various state and local elections to fill Indiana's class III United States Senate seat. Incumbent Democratic Senator Evan Bayh decided in February 2010 to retire instead of seeking a third term shortly after Dan Coats announced his candidacy. Bayh's announcement came one day before the filing deadline and no Democratic candidate submitted enough signatures by the deadline to run, so the State Democratic Party chose U.S. Congressman Brad Ellsworth as their nominee. The Libertarian Party nominated YMCA instructor Rebecca Sink-Burris, who had previously unsuccessfully run for this seat in 1998. Coats won the open seat; having previously held it from 1989 to 1999. Bayh later unsuccessfully ran for this seat again in 2016.

Marlin Andrew Stutzman is an American politician who was a member of the United States House of Representatives, representing Indiana's 3rd congressional district, from 2010 to 2017. A Republican, Stutzman previously served as a member of the Indiana House of Representatives from 2002 to 2008, representing district 52, and as a member of the Indiana Senate, representing the 13th district, from 2009 to 2010.